Kinase Binding Kinetics Profiling
Kinetic data increases the chances of clinical effectiveness
Compounds with identical affinity for a given target can exhibit different kinetic profiles which may result in the differentiation of the clinical responses: greater efficacy and tolerability, longer response and different therapeutic indications.
We offer the analysis of the kinetic profile of your compounds for parallel SAR and SKR studies.
We use a fast and simple method to measure the affinity constant (Kd), the association rate constant (kon), the dissociation rate constant (koff) and the residence time of your compounds.
Features & benefits:
• Identification of compounds with the desired kinetic parameters as an efficient starting point for lead development
• Parallel optimization of binding affinity and binding kinetics
• Evaluation of both active and inactive kinases
• Rapid turnaround time
• Accurate and reproducible data
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