Product


Kinase Binding Mechanism Characterizaction
Beyond potency measurements
Kinases adopt a variety of conformations to exert their biological role. Conformational adaptation implies the variation of the size and availability of binding sites, which paves the way for designing new drugs.
Enzymlogic determines the binding mechanism of your compounds to provide you with structural information in early stages.
 
Features & benefits:

• To obtain structural information when the kinase of your interest cannot be crystallized
• To relate binding mechanism, kinetic parameters and activity to drug structure in the optimization process
• To select and design compounds with non-classical binding to the kinase ATP site
• To determine whether the interaction is simple reversible, reversible with isomerization, reversible with conformational selection or irreversible
 
 
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