Product


NFX81
Effect of LPA181 (LP181A1 in the chart) on the mobility of rats (time spent on rotarod) after spinal cord injury for 28 days. Rats treated with LPA181 (open squares) had marked and significant motor recoveries compared with control rats (solid circles). The solid squares show the result with another compound of the series, LP181
NFX81 is a synthetic monounsaturated fatty acid derivative which shows great potency in the treatment of Spinal Cord Injury (SCI), achieving mobility recovery of up to 80% in animal models after 4 weeks treatments, whereas control animals recover just 10 to 15% of their mobility.
 
NFX81 is a synthetic monounsaturated fatty acid derivative which shows great potency in the treatment of Spinal Cord Injury (SCI), achieving mobility recovery of up to 80% in animal models after 4 weeks treatments, whereas control animals recover just 10 to 15% of their mobility. Very promising responses has also been observed in animal models of SCI neuropathic pain.Moreover, NFX81 and other MLT-based compounds in our pipeline, seem to have a significant potential in treating Neuropathic pain and other SCI-related lesions, such as sensitivity loss. In this context, preliminary results with NFX81, after 7 days treatments, show a marked capacity of blocking mechanical hypersensitivity in rats after spared nerve injury (measured by normalized Von Frey threshold) and also a clear trend for anti-nociception.

In collaboration with researchers at the Paraplegics National Hospital in Toledo (Spain), additional studies are currently in progress to further develop the potential applications of NFX81 in this field and to elucidate the molecular mechanisms of action behind this outstanding efficacy observed in animal models of SCI.

Neurofix has in-licensed rights for NFX81, a Spanish biopharmaceutical company, as of February 2016
 
 
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