Macrocycles: An Increasingly Popular Strategy in Drug Design
Join us on December 5th at 8am PT/ 11am ET/ 4pm GMT for an in-depth exploration of macrocycles in drug design and discovery!
In this webinar, Mike Waring, Professor and Head of Medicinal Chemistry at Newcastle University, and Sébastien Campos, Senior Director of Medicinal Chemistry at Pharmaron, will explore how macrocycles are transforming the field. Discover key principles for rational macrocycle design and learn about the unique benefits and challenges of this compound class.
Dont´s miss the opportunity to gain insights from leading experts in the field -reserve your spot today!
Register here:
https://pharmaron.zoom.us/webinar/register/6017314963012/WN_Ky3L_BcNSoCA3WF5YqPlpQ
This webinar will review the emergence of macrocycles as a powerful strategy in drug design and dicovery, highlighting the principles of rational design and the benefits and challenges of this class of compounds.
Agenda
- Introduction to macrocycles
- What are macrocyclic drugs?
- What are their advantages compared to theis acyclic counterparts?
- Macrocycle rational design
- What are the strategies to design successful macrocycles?
- What are the known principles for the optimization of physicochemical properties?
- Case Study: the discovery of a novel series of PKC0 inhibitors with exquisite potency and isoform selectivity
- Success and challenges throughout the lead optimization process