ORYZON announces oral data presentation at the upcoming 64th American Society of Hematology annual conference
Final data of Phase II ALICE trial in unfit AML patients treated with iadademstat and azacitidine
Oryzon Genomics, S.A. (ISIN Code: ES0167733015, ORY), a clinical-stage biopharmaceutical company leveraging epigenetics to develop therapies in diseases with strong unmet medical need, today announced that its communication reporting final data from its ongoing and fully accrued Phase IIa ALICE trial, investigating iadademstat in combination with azacitidine in elderly or unfit patients with acute myeloid leukemia (AML), has been selected for oral presentation at the upcoming 64th American Society of Hematology (ASH) Annual Meeting and Exposition, to be held December 10-13, 2022 in New Orleans.
The communication entitled “Iadademstat Combination with Azacitidine Is a Safe and Effective Treatment in First Line Acute Myeloid Leukemia. Final Results of the ALICE Trial” will be presented as an oral presentation by Dr. Olga Salamero, MD from the Vall d’Hebron Hospital in Spain, during Session 616: “Acute Myeloid Leukemias: Investigational Therapies, Excluding Transplantation and Cellular Immunotherapies: Frontline and Maintenance”, on Monday December 12th at 11.15 am ET at the Ernest
N. Morial Convention Center, room 275-277.
Dr. Carlos Buesa, Oryzon’s CEO, said: "These results confirm previous data in supporting a strong synergy between iadademstat and azacitidine in combination. It is highly encouraging that we continue to see high levels of response and extended remissions, alongside good tolerability. We feel honored by this selection for an oral presentation and this reflects the interest for the therapeutical potential of the LSD1 inhibition in the field”
Dr. Douglas Faller, Oryzon’s Global CMO, stated: “Combinations with iadademstat have the potential to significantly improve patient outcomes and will increase therapeutic options for AML patients not only in first line, but also in patients who are refractory or intolerant to BCL2 inhibitors. To further investigate iadademstat’s activity in second line AML, Oryzon is launching FRIDA, a new clinical trial with iadademstat in combination with gilteritinib in FLT3-mutant relapsed/refractory AML patients.”
The abstract for the above communication is now available on the ASH website at www.hematology.org. A copy of the presentation will be available on Oryzon’s website at www.oryzon.com following presentation at the meeting.