ORYZON strengthens patent portfolio for vafidemstat with new Decision to Grant in Japan
For the treatment of aggression and social withdrawal.
Oryzon Genomics, S.A. (ISIN Code: ES0167733015, ORY), a clinical-stage biopharmaceutical company and a global leader in epigenetics, today announced that it has received a “Decision to grant” communication from the Japanese Patent Office for its patent application JP2023-136283, titled “Methods of treating behavior alterations”, related to vafidemstat, Oryzon’s LSD1 inhibitor in clinical development for the treatment of psychiatric disorders.
The allowed claims cover the use of vafidemstat for the treatment of aggression and social withdrawal – two symptoms associated with several CNS disorders. Oryzon is preparing a Phase III trial to evaluate vafidemstat for the treatment of aggression in borderline personality disorder (BPD). The Company is also preparing a Phase II trial in aggression in autism spectrum disorder (ASD) patients, and a Phase II trial is already ongoing in schizophrenia.
A “Decision to grant” is an official communication from a national patent office indicating that a patent application has met all requirements for issuance as a granted patent. Once formally granted, this Japanese patent will remain in force until at least 2038, excluding any potential patent term extension, which could provide additional years of protection. Corresponding patents have already been granted or allowed in Europe, Australia, Canada, Hong Kong, Israel, South Korea, Malaysia, the Philippines, and Russia, and additional applications are pending in other countries.
“This patent allowance in Japan further expands our global patent portfolio and strengthens Oryzon’s IP position for vafidemstat, protecting key therapeutic indications under clinical development and supporting its long-term commercial potential”, said Neus Virgili, Oryzon’s Chief IP Officer.
In addition to this patent family, Oryzon holds other patents covering the use of vafidemstat for the treatment of CNS disorders, including a patent family directed to the treatment of BPD or non-aggressive symptoms of BPD, with patents granted or allowed in Europe, Australia, Japan, Mexico, Russia, Singapore, and South Africa, and additional applications pending in other countries. These patents are expected to remain in force until at least 2040, excluding any potential patent term extensions.