ORYZON announces appointment of Douglas V. Faller, MD, PhD as Global Chief Medical Officer and continues its expansion of US corporate activities

Oryzon Genomics, S.A. (ISIN Code: ES0167733015, ORY), a public clinical-stage biopharmaceutical company leveraging epigenetics to develop therapies in diseases with strong unmet medical need, announced today the appointment of Douglas Faller, M.D., Ph.D., to the role of Global Chief Medical Officer. Dr. Faller has over 30 years of clinical hematology/oncology expertise and broad drug development experience in the design and execution of early to registrational clinical programs across oncology and rare diseases and will lead Oryzon’s global clinical development strategy. Based in Boston, Dr. Faller will strengthen Oryzon's permanent presence in the US as it builds up strategic partnerships with US hospitals and research institutions to develop its pipeline and clinical programs.

Dr. Faller’s extensive scientific and clinical research experience in hematology and oncology, as well as in other non-oncological and rare diseases, will be key in developing Oryzon’s portfolio. He joins Oryzon from Takeda, where he was Executive Medical Director and Global Clinical Leader for more than 5 years. Dr. Faller holds a medical degree from Harvard University and a Ph.D. in Cancer Molecular Biology from M.I.T. He was Professor of Medicine at Harvard Medical School, and subsequently he founded and served as first Director of Boston University Cancer Center where he was also Grunebaum Professor for Cancer Research, and Professor of Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine. He has founded several biotech companies, some of them currently listed in Nasdaq, and has previously served as the Chief Medical Officer and Chief Scientific Officer of Viracta Therapeutics, Inc (VIRX).

Dr. Carlos Buesa, President and CEO of Oryzon said: “Dr. Faller is an outstanding clinical hematologist and oncologist with a proven track record of driving the design and execution of early, mid- and global latestage clinical programs. His extensive experience in interactions with US and global regulatory agencies and seniority in oncology development, in both academic and industry settings, will be invaluable as we continue to expand our pipeline. His appointment further reinforces Oryzon’s US footprint as our medical and business operations progressively gravitate towards this major market.”

Dr. Faller said: “With multiple ongoing Phase II trials spanning both oncological and CNS diseases, and with at least two new clinical trials planned to start this year, all utilizing Oryzon’s potentially best-in-class medicines, the company is well positioned to make a meaningful impact in the treatment of some of the most underserved therapeutic areas in cancer and CNS diseases. Our goal is to develop our precision, targeted therapies with iadademstat in oncology, and to pioneer a personalized medicine approach with vafidemstat in neuropsychiatric and neurodevelopmental disorders. I look forward to working with the talented scientists and a dedicated team at Oryzon to advance the corporate mission of helping people with cancers or debilitating CNS disorders to lead longer and better lives."

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