ORYZON expands patent protection for iadademstat with grant decision in Mexico covering combinations with PD-1/PD-L1 inhibitors

Oryzon Genomics, S.A. (ISIN Code: ES0167733015, ORY), a clinical-stage biopharmaceutical company and global leader in epigenetics, today announced that the Mexican Patent Office has issued a decision to grant for its patent application MX/a/2021/011610, entitled “Combinations of iadademstat for cancer therapy”.

The allowed claims protect the use of iadademstat in combination with PD-1 or PD-L1 inhibitors for the treatment of cancer, including small cell lung cancer (SCLC). Following formal grant, the patent is expected to provide protection until at least 2040, not including any potential patent term extensions. With this decision, Oryzon has now secured patent protection for these combinations in Australia, Europe, Japan, Mexico and Russia, while corresponding patent applications remain under examination in other jurisdictions.

“This decision further strengthens the global intellectual property protection around iadademstat and its use in combination therapies,” said Neus Virgili, Oryzon’s Chief IP Officer. “Securing protection in additional countries supports the development of iadademstat with immune checkpoint inhibitors such as atezolizumab and durvalumab, an approach we are exploring in small cell lung cancer.”

Iadademstat is currently being investigated in combination with PD-L1 inhibitors in extensive-stage SCLC (ES-SCLC) in two ongoing clinical trials. One is a Phase I/II study evaluating iadademstat in combination with atezolizumab or durvalumab, conducted and sponsored by the U.S. National Cancer Institute (NCI) under a Cooperative Research and Development Agreement (CRADA) with Oryzon, and carried out at more than 30 clinical sites across the United States. The other is an open-label Phase Ib study sponsored and conducted by Yale University, evaluating iadademstat in combination with atezolizumab and stereotactic body radiation therapy (SBRT), followed by maintenance therapy with atezolizumab and iadademstat in patients with residual, progressive or recurrent ES-SCLC.