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ORYZON secures another important patent for its lead CNS asset, vafidemstat

Has received “Intention to Grant” from the European Patent Office. 

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Oryzon Genomics S.A., a clinical-stage biopharmaceutical company leveraging epigenetics to develop therapies in diseases with strong unmet medical need, announced today that the European Patent Office (EPO) has issued an “intention to grant” communication for Oryzon’s European patent application EP18748921.6 entitled “Methods of treating behavior alterations” related to vafidemstat, Oryzon’s LSD1 inhibitor in clinical development for the treatment of psychiatric disorders like borderline personality disorder and schizophrenia. The allowed claims cover the use of vafidemstat for the treatment of aggression and social withdrawal. 

The intention to grant is a formal communication from the EPO in which it indicates that the patent application has reached the status where it is allowed for issuance as a patent. The patent, once granted, will not expire until at least 2038, excluding any potential patent term extensions that may provide additional protection. Corresponding patent applications are pending in several additional major pharmaceutical markets, and a patent has already been granted in Russia. 

“Vafidemstat is protected by an extensive array of issued patents safeguarding its composition-of-matter across key global markets, complemented by a multilayer of supplementary patent filings that will offer additional market exclusivity when granted. We are delighted to have received this notice of intention to grant from the European Patent Office. This decision reinforces and validates our overall IP strategy”, said Neus Virgili, Chief IP Officer of Oryzon. “Upon issuance, this patent will significantly enhance Oryzon’s patent portfolio for vafidemstat, extending its commercial life in indications with large commercial potential”, stated Dr. Carlos Buesa, Chief Executive Officer of Oryzon.

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